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KMID : 0644319980040010111
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Journal of Korean Oriental Oncology
1998 Volume.4 No. 1 p.111 ~ p.129
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Effect of Sipjundaebotang on the immune response of CD4+ and CD8+ T cell in rats
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高渶權/Ko, Young-Kwon
柳逢夏/朴東源/柳基遠/Ryu, Bong-Ha/Park, Dong Won/Ryu, Ki Won
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Abstract
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In order to research the effect of Sipjundaebotang on the immune respons of CD4+ T cell and CD8+ T cell in rats, author have performed this experimental study.
Experimental geoups are divided into 5 groups(intact, control, sampleⅠ, sampleⅡ, sampleⅢ). Normal group was intact, control group was administrated normal saline 2cc for 5 datys, sampleⅠ was administrated low concentration of Sipjundaevotang(100/3100pack/ml)2cc for 5 datys, sampleⅠ was administrated middle concentration of Sipjundaevotang(500/3100pack/ml)2cc for 5 datys, sampleⅡ was administrated middle concentration of Sipjundaevotang(500/3100pack/ml)2cc for 5 datys, sampleⅢ was administrated high concentration of Sipjundaevotang(2500/3100pack/ml)2cc for 5 datys.
WBC, Lymphocyte, CD4+ T cell in the blood, spleen, axillary node and CD8+ T cell in the blood, spleen and axillary node were determined.
The results was as follows:
1. WBC count in blood was signififcantly decreased in the control, sample Ⅰ, Ⅱ, Ⅲgroups as compared with the normal group.
2. Lymphocyte count in the blood was significantly decreased in the control, sample Ⅰ, Ⅱgroups as compaared with the normal group.
3. CD4+ T cell count in the blood was significantly increased dose-dependently in the sampe Ⅰ, Ⅱgroups as compared with the mormal group.
4. CD4+ T cell count in the spleen was significantly increased in the sampleⅠ, Ⅱ, Ⅲgroups as compared with the mormal group.
5. CD4+ T cell count in the axillary node was significantly increased in the sampleⅢgroup as compared with the normal group. however significantly decreased in the sampleⅠ, Ⅱgroups as compared with the mormal group.
6. CD8+ T cell count in the blood was significantly increased in the sampleⅢgroup as compared with the normal group.
7. CD8+ T cell count in the splecn was significantly increased in the sample Ⅰ,Ⅱ,Ⅲgroup as compared with the normal group. but there was no differences inthe sample groups.
8. CD8+ T cell count in the axillary node was decreased in the smpleⅠ,Ⅱgroups as compared with the normal group.
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KEYWORD
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